Aromatic fluorination with xenon difluoride: L-3,4-dihydroxy-6-fluoro-phenylalanine
- 15 July 1980
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 58 (14) , 1449-1450
- https://doi.org/10.1139/v80-228
Abstract
L-3-Methoxy-4-hydroxyphenylalanine was fluorinated directly with XeF2 in CH2Cl2 at −60 °C invacuo. After hydrolysis with 48% aqueous HBr, L-6-fluorodopa was obtained. The yield, based on XeF2, was 25%. This reaction might be applied when chiral biomolecules are to be tagged with fluorine-18.Keywords
This publication has 0 references indexed in Scilit: