Metabolic activation of benzo[a]pyrene by a human hepatoma cell line
- 1 October 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 1 (10) , 871-875
- https://doi.org/10.1093/carcin/1.10.871
Abstract
The liver-derived human cell line, Hep G2, has high benzo[a]pyrene-metabolizing activity and converts benzo[a]pyrene to intermediates that are mutagenic and that bind to DNA. This cell line will be useful for studying metabolic activation of polycyclic aromatic hydrocarbons and other xenobiotics by human tissue and as an activation system in short-term screening assays for identifying compounds with carcinogenic potential for humans.Keywords
This publication has 2 references indexed in Scilit:
- State of hepatitis B viral DNA in a human hepatoma cell lineJournal of Virology, 1980
- (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene: a potent skin carcinogen when applied topically to mice.Proceedings of the National Academy of Sciences, 1976