Preloading and the regulation of food intake in man.

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Abstract
17 human Ss ate 20-min meals of Metrecal through a straw connected to a hidden reservoir. Oral preloads of Metrecal were administered before the meals, and these varied 20-120% of the amount of the base-line meal intake and were given 1-120 min. before the meal. Test-meal intake was depressed as a function of the size of the preload; however, the Ss did not take the preload fully into account and they overate. Depression of intake was maximal 1-5 min. for some Ss and 15-30 min. for others. Subjective ratings of hunger paralleled the variations in intake produced by preloading. The results are discussed in terms of the joint operation of oropharyngeal and gastric postingestional factors. (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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