Mammary Tumorigenesis in Chemical Carcinogen-Treated Mice. II. Dependence on Hormone Stimulation for Tumorigenesis2
- 1 July 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 53 (1) , 223-226
- https://doi.org/10.1093/jnci/53.1.223
Abstract
The importance of hormone stimulation con-comitant with treatment with 3-methylcholanthrene (MCA) for induction of a high incidence of mammary tumors was investigated in BALB/c mice. Hormone stimulation of the mammary glands proved essential for induction of a high incidence of carcinogen-altered cells soon after treatment with low doses of carcinogen, and it facilitated the expression of the carcinogen-altered cells as mammary tumors. Adenoacanthomas appeared during or just after intense hormone stimulation of the mammary gland, whereas type-B mammary adenocarcinomas appeared within a resting, regressed mammary gland. Similarly, there were no hyperplastic aveolar nodules in MCA-treated BALB/c mic.Keywords
This publication has 0 references indexed in Scilit: