Alpha-radiation-induced amplification of integrated sv40 sequences is mediated by atrans-acting mechanism
- 14 January 1987
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 39 (1) , 94-98
- https://doi.org/10.1002/ijc.2910390117
Abstract
Treatment of Chinese hamster embryo cells with alpha irradiation (4 MeV, emitted by 241americium) induces a 15-fold amplification of integrated SV40 sequences. The extent of amplification depends on the dose of irradiation and on the presence of a functional T-antigen encoded by the SV40 A gene. The inducing signal can be transmitted to a non-irradiated nucleus following cell fusion. Amplification is therefore the result of some trans-acting process, and this could explain how SV40 amplification can occur after doses of alpha irradiation that are too low to cause direct DNA damage within the SV40 replicon.This publication has 37 references indexed in Scilit:
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