Differences in metabolite levels upon differentiation of intact neuroblastoma × glioma cells observed by proton NMR spectroscopy
- 17 October 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 162 (2) , 320-323
- https://doi.org/10.1016/0014-5793(83)80780-7
Abstract
Proton NMR spectroscopy was used to study the effect of differentiation with prostaglandin E1 and theophylline on intact hybrid neuroblastoma × glioma cells. The standard proton NMR method showed more resolvable signals than the spin echo NMR spectra. The differentiated cells were found to contain significantly higher levels of glutamine than the undifferentiated precursors. Observations on cell extracts confirmed these resultsKeywords
This publication has 6 references indexed in Scilit:
- Selective observation of 13C-enriched metabolites by 1H NMRJournal of Magnetic Resonance (1969), 1983
- Induction of Glutamine Synthetase by Dibutyryl Cyclic AMP in C‐6 Glioma CellsJournal of Neurochemistry, 1982
- Derepression of the Glutamine Synthetase in Neuroblastoma Cells at Low Concentrations of GlutamineJournal of Neurochemistry, 1982
- Proton Nuclear Magnetic Resonance of Intact Friend Leukemia Cells: Phosphorylcholine Increase During DifferentiationScience, 1982
- Selective excitation in Fourier transform nuclear magnetic resonanceJournal of Magnetic Resonance (1969), 1978
- 31P nuclear magnetic resonance studies of Ehrlich ascites tumor cells.Proceedings of the National Academy of Sciences, 1977