Effect of Indomethacin on Monoamine Metabolism and Melatonin Synthesis in Rat Pineal Gland
- 1 January 1980
- journal article
- research article
- Published by S. Karger AG in Hormone Research
- Vol. 12 (6) , 305-312
- https://doi.org/10.1159/000179136
Abstract
Indomethacin treatment of rats resulted in a significant increase of pineal monoamine oxidase (MAO) type A activity, whereas it depressed MAO type B and hydroxyindole-O-methyl transferase activities. Indomethacin also significantly impaired the nocturnal rise of pineal serotonin-N-acetyltransferase activity and melatonin content. These results suggest a role for prostaglandins in the regulation of pineal function.Keywords
This publication has 8 references indexed in Scilit:
- Melatonin blocks in vitro generation of prostaglandin by the uterus and hypothalamusEuropean Journal of Pharmacology, 1980
- Release and specific binding of prostaglandins in bovine pineal glandProstaglandins, 1979
- Effects of Castration and Reproductive Hormones on Pineal Serotonin Metabolism in RatsNeuroendocrinology, 1979
- DETERMINATION OF A DARK-INDUCED INCREASE OF PINEAL N-ACETYL TRANSFERASE ACTIVITY AND SIMULTANEOUS RADIOIMMUNOASSAY OF MELATONIN IN PINEAL, SERUM AND PITUITARY TISSUE OF THE MALE RATJournal of Endocrinology, 1977
- Melatonin in Rat Pineal, Plasma, and Urine: 24-Hour Rhythmicity and Effect of ChlorpromazineEndocrinology, 1976
- Decrease of serotonin N-acetyltransferase activity in rat pineal organs after treatment with prostaglandin synthesis inhibitor indomethacinProstaglandins, 1976
- Enzymatic O-Methylation of N-Acetylserotonin to MelatoninScience, 1960
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951