Parathyroid adenomas evaluated by Tl-201/Tc-99m pertechnetate subtraction scintigraphy and high-resolution ultrasonography.

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Abstract
201Tl/99mTc pertechnetate subtraction scintigraphy of the parathyroid glands was performed in a prospective study of 33 patients who had undergone bilateral neck exploration for elevated serum Ca and serum parathyroid hormone levels. In 31 cases, the 201Tl/99mTc subtraction technique yielded an overall sensitivity of 81%, specificity of 99% and accuracy of 94% for identifying solitary parathyroid adenomas. 201Tl/99mTc subtraction scintigraphy correctly identified 73% of parathyroid adenomas weighing < 499 mg, 79% of those weighing 500-1499 mg and 100% of adenomas weighing > 1500 mg. In a subgroup of 24 patients with solitary parathyroid adenomas who underwent both scintigraphy and high-resolution sonography, the sensitivity, specificity and accuracy of both procedures were similar.

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