Faculty Opinions recommendation of Pleiotropic effects of beneficial mutations in Escherichia coli.

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Abstract
This is one of the first studies to thoroughly explore the pleiotropic effects of beneficial mutations, a key issue in the evolution of specialization and adaptation. Using replicate lines of E. coli, they identify 27 beneficial mutants that increase fitness on glucose, and quantify fitness of each mutant on five novel resources. Contrary to most theoretical models of adaptation, pleiotropy was predominantly positive; negative pleiotropy was detected on only one resource and only in a subset of mutants.

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