While the suspected diagnosis of agammaglobulinemia is being made with increasing frequency, it is not a common condition. Barrett and Volwiler (4) have stressed the need for correct diagnosis of the condition. I studied 52 patients with long-standing bronchiectasis and failed to find a single instance of deficiency of gamma globulin in an ambulatory patient. One case of severe hypogammaglobulinemia in a woman with bronchiectasis is reported, with the results of 4 years of replacement therapy.