Waldenström's Macroglobulinemia With Generalized Amyloidosis
- 1 October 1966
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 118 (4) , 363-375
- https://doi.org/10.1001/archinte.1966.00290160063013
Abstract
THE HE COEXISTENCE of two diseases in one individual is of particular interest when one or both are of uncertain etiology, since it raises the question whether these diseases are etiologically interrelated, or only fortuitously associated. Multiple myeloma1and Waldenström's macroglobulinemia2are two closely related proliferative disorders of plasma cells,3the precise etiology of which still remains unknown. Generalized amyloidosis,4which is frequently associated with multiple myeloma,5may also represent a disorder of plasma cells.6This communication concerns a patient with macroglobulinemia of Waldenström who was found, at autopsy, to have generalized amyloidosis, an association which has been previously recorded only 11 times.2,6-18This report and the discussion which follows will attempt to illustrate and summarize some of the unifying concepts on the pathogenesis of these reticuloendothelial diseases. Report of a Case A 56-year-old mining foreman (21-54-24) was admitted for the first time to the Royal Victoria Hospital,Keywords
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