Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms
Top Cited Papers
- 1 January 2004
- journal article
- review article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 369 (1) , 89-104
- https://doi.org/10.1007/s00210-003-0819-z
Abstract
The cytochrome P450s are responsible for about 75% of phase I dependent drug metabolism and for the metabolism of a huge amount of dietary constituents and endogenous chemicals. The human has 59 active genes, and 6 of those encode important drug metabolising enzymes. About 40% of cytochrome P450 dependent drug metabolism is catalysed by polymorphic enzymes and such drug P450 interactions are frequently seen in adverse drug reaction reports. In this contribution an update of human cytochrome P450 enzymology and pharmacogenetics is given with particular emphasis on CYP1B1, CYP2B6, CYP2E1 and CYP3As.Keywords
This publication has 98 references indexed in Scilit:
- Cloning and Tissue Distribution of a Novel Human Cytochrome P450 of the CYP3A Subfamily, CYP3A43Biochemical and Biophysical Research Communications, 2001
- Identification and Tissue Distribution of the Novel Human Cytochrome P450 2S1 (CYP2S1)Biochemical and Biophysical Research Communications, 2001
- Structural and Functional Characterization of the 5′-Flanking Region of the Rat and Human Cytochrome P450 2E1 Genes: Identification of a Polymorphic Repeat in the Human GeneBiochemical and Biophysical Research Communications, 1999
- Evidence for the Presence of a Functional Pregnane X Receptor Response Element in the CYP3A7 Promoter GeneBiochemical and Biophysical Research Communications, 1999
- Interindividual Differences in Hepatic Expression of CYP3A4: Relationship to Genetic Polymorphism in the 5′-Upstream Regulatory RegionBiochemical and Biophysical Research Communications, 1999
- Cytochrome P450 3AClinical Pharmacokinetics, 1999
- P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclaturePharmacogenetics, 1996
- Transcriptional control of CYP2E1 in the perivenous liver region and during starvationBiochemical and Biophysical Research Communications, 1990
- Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liverBiochemical and Biophysical Research Communications, 1988
- Ligand-dependent maintenance of ethanol-inducible cytochrome P-450 in primary rat hepatocyte cell culturesBiochemical and Biophysical Research Communications, 1988