VARIATIONS IN THE BASOPHILIA OF NERVE CELLS ASSOCIATED WITH INCREASED CELL ACTIVITY AND FUNCTIONAL STRESS

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Abstract
Nerve cells were stained with gallocyaninchromalum for quantitative and stoicheiometrical demonstration of nucleic acids which were found to vary markedly with functional and pathological activity. There were variations in the basophilia of cytoplasm, nucleus, nucleolus and nuclear membrane; accompanied by alterations in the form of the cell body and nucleus, and nucleolar size. There were characteristic changes in the distribution of the basophilic elements in the cytoplasm and nuclear displacement. Variations in basic staining reaction occur constantly in normal animals and man but are magnified by experimental procedures and disease. Chromophobia follows pathofunctional stress in man and in ganglion cells of Aplysia after electric stimulation and are probably traceable to increased activity and abnormal neuronal discharge.
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