QUALITY-CONTROL OF TC-99M DTPA FOR MEASUREMENT OF GLOMERULAR-FILTRATION - CONCISE COMMUNICATION

  • 1 January 1983
    • journal article
    • research article
    • Vol. 24  (8) , 722-727
Abstract
When 99mTc DTPA [diethylenetetramine pentaacetic-acid] is used to measure glomerular filtration rate (GFR), accuracy depends on the radiopharmaceutical supplier. The GFR error is due to protein binding, as shown by direct measurement in humans and mice. In 19 patients, GFR measured with Tc-DTPA and corrected for protein binding agreed with that measured simultaneously using Yb-169 DTPA (correlation coefficient 0.991). Without correction, Tc-DTPA gave fasely low values in patients having good renal function, in whom unbound activity cleared rapidly while bound activity remained in the circulation. When Tc-DTPA is used to measure GFR, in vivo protein binding should be measured and used to correct data.

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