Reported Outcomes in Major Cardiovascular Clinical Trials Funded by For-Profit and Not-for-Profit Organizations: 2000-2005
Open Access
- 17 May 2006
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 295 (19) , 2270-2274
- https://doi.org/10.1001/jama.295.19.2270
Abstract
Surveys of randomized trials published between 1990 and 2000 raised awareness in the medical community that trials funded by for-profit organizations were more likely to report positive findings than those funded by not-for-profit organizations.1-8 As a group, these surveys raised questions regarding the design and conduct of industry-funded clinical trials9-11 as well as ethical concerns about potential violations of clinical equipoise.12-15 Partly in response to these concerns, recommendations have been made to improve academic oversight in industry-sponsored research16,17 and to ensure registration and publication of all clinical trials.18,19Keywords
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