Genetic screening with the DNA chip: a new Pandora's box?
Open Access
- 1 April 1999
- journal article
- research article
- Published by BMJ in Journal of Medical Ethics
- Vol. 25 (2) , 200-203
- https://doi.org/10.1136/jme.25.2.200
Abstract
The ethically controversial option of genetic population screening used to be restricted to a small number of rather rare diseases by methodological limitations which are now about to be overcome. With the new technology of DNA microarrays ("DNA chip"), emerging from the synthesis of microelectronics and molecular biology, methods are now at hand for the development of mass screening programmes for a wide spectrum of genetic traits. Thus, the DNA chip may be the key technology for a refined preventive medicine as well as a new dimension of eugenics. The forthcoming introduction of the DNA chip technology into medical practice urgently requires an internationally consistent framework of ethical standards and legal limitations if we do not want it to become a new Pandora's box.Keywords
This publication has 22 references indexed in Scilit:
- Multiplex Genetic TestingHastings Center Report, 1998
- Cost effectiveness of DNA diagnosis for four monogenic diseases.Journal of Medical Genetics, 1997
- Genetic screening: a comparative analysis of three recent reports.Journal of Medical Ethics, 1997
- Genetic Information and the Workplace: Legislative Approaches and Policy ChallengesScience, 1997
- Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two–colour fluorescence analysisNature Genetics, 1996
- To affinity … and beyond!Nature Genetics, 1996
- Accessing Genetic Information with High-Density DNA ArraysScience, 1996
- COUPLE-BASED PRENATAL SCREENING FOR CYSTIC FIBROSIS IN PRIMARY CARE SETTINGSPrenatal Diagnosis, 1996
- Genetic and Environmental Effects on Urinary Kallikrein, Catecholamines, Sodium, Potassium, Urea Nitrogen and Inorganic Sulfate Sulfur Levels in School-Age TwinsHuman Heredity, 1996
- Genetic Discrimination and Health Insurance: An Urgent Need for ReformScience, 1995