The Use of Specific Radioimmunoassays to Determine the Renal Clearance Rates of Estrone and 17β-Estradiol during the Menstrual Cycle*
- 1 November 1978
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 47 (5) , 1084-1091
- https://doi.org/10.1210/jcem-47-5-1084
Abstract
Specific RIAs requiring ether extraction only were established for estrone and 17β-estradiol both in plasma and in urine from the nonpregnant female. These assays were used to measure the renal clearance rates of estrone and of 17β-estradiol in eight ambulatory women in the follicular and in the luteal phases of the menstrual cycle. The mean (±SE) for the renal clearance rate of estrone was 0.71 ± 0.058 ml/min in the follicular phase and 1.26 ± 0.35 ml/min in the luteal phase. The mean (±SE) renal clearance rate of 17β-estradiol was 0.44 ± 0.055 ml/min in the follicular phase and 0.29 ± 0.043 ml/min in the luteal phase. There was no significant difference in the renal clearance rates of either estrone or of 17β-estradiol between the follicular and luteal phases of the cycle. The renal clearances of estrone and 17β-estradiol were highly correlated (r = 0.84; P < 0.01). The renal clearance rate of estrone was significantly greater than that of 17β-estradiol in both phases of the cycle (P < 0.01).Keywords
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