Hypersarcosinemia

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Abstract
A NEW inborn error of amino acid metabolism, hypersarcosinemia with sarcosinuria, was recently reported by us.1 , 2 A ten-month-old male infant who excreted sarcosine, and who had difficulty in swallowing and failure to thrive throughout infancy, was discovered after he was committed to the Central Wisconsin Colony and Training School, a state institution for the mentally retarded. Sarcosine has no known specific role in mammalian metabolism other than being the intermediate between dimethylglycine (DMG) and glycine in the 1-carbon cycle.'1 This amino acid has been reported to be in the protein of the peanut4 and a constituent of the actinomycins.5 The . . .