Measurement of regional cerebrovascular haemoglobin oxygen saturation in cats using optical spectroscopy

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Abstract
We describe the use of optical spectroscopy in the near infra-red light range to non-invasively measure regional cerebral haemoglobin oxygen saturation (rSHbO2) in cats during progressive cerebral hypoxia. This technique differs from spectroscopic techniques previously described in that the concentration ratio - percentage haemoglobin: oxygen saturation - is quantified. This saturation is the weighted summation of saturation in the cerebrovascular system: arterial, venous, and capillary beds. In a cat model of progressive cerebral hypoxiai, a positive linear correlation between this regional measurement of cerebral saturation and actual saturation, calculated from cerebral arterial and mixed venous blood, was noted (n=20, r=0.88, p2 is also used to index cerebral oxygen extraction. During hypoxia spectroscopic indexed oxygen extraction (iOE) and cerebral arterial-venous difference in oxygen content were simultaneously measured. A least-squares positive linear correlation between these two parameters was noted [AVDO2 = iOE(0.05) + 4.4] (n = 40, r = 0.6, s = 1.2). Objective measurement of ‘regional cerebrovascular haemoglobin saturation’ and an index of cerebral oxygen extraction are possible using optical spectroscopy.

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