Transplantation Immunology

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Abstract
UNDERSTANDING the success or failure of transplantation of an allograft involves consideration of the antigens on the transplanted tissue that are recognized by the recipient as foreign and that can evoke the rejection response, the cells in the recipient's immune system that mediate rejection, and the reactions that modify either the presentation of the foreign antigen or the cellular response. In this article, we review the impact of each of these considerations on current research in transplantation immunology.The Major Histocompatibility ComplexIn every mammalian species that has been studied, a single genetic complex codes for cell-surface histocompatibility antigens that . . .