THE WORK PERFORMANCE OF NORMAL RATS GIVEN CONTINUOUS INTRAVENOUS INJECTIONS OF CORTISONE AND OF CORTICOTROPIN

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Abstract
DURING the past 20 years there have been a number of reports that normal animals can be made more resistant to fatigue by the administration of adrenal cortical extracts. One of us (DJI) has made several attempts to confirm these claims with negative results. One of our studies (Ingle, Nezamis and Jeffries, 1949) has been published. The present report is based upon positive results obtained by the continuous intravenous injection of either cortisone or corticotropin. methods Male rats of the Sprague-Dawley strain were obtained from the Upjohn breeding colony and maintained on Archer Dog Pellets until they reached a weight of 200±2 gms. The work test was carried out according to Ingle (1944). The animals were anesthetized with phenobarbital sodium and cyclopal sodium and were subjected to the stimulation of muscle immediately following hypophysectomy. The gastrocnemius muscle of the left hind leg was weighted with 100 gms. A Nerve Stimulator, Model B (Upjohn) was used to deliver 5 pulses per second.

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