Effects of Sympathetic Blockade Drugs on Ventricular Tachycardia Resulting From Myocardial Infarction

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Abstract
Experiments to determine the ectopic impulse suppressor effects of certain sympathetic blockade drugs upon administration to dogs with ventricular tachycardia resulting from myocardial infarction are described. Some reduction in ectopic activity was produced by each of the compounds tested: dihydroergotamine, Dibenamine (N-(2-chloroethyl)dibenzylamine), dibenzyline, regitine, and Priscoline (2-benzyl-2-imidozoline hydrochloride). All of these drugs were given intravenously, and in some additional experiments regitine was injected into the occluded coronary artery distal to the ligature. The most nearly complete ectopic suppressor effect was obtained by dibenzyline, i.v., in small doses, Regitine by intracoronary injection in small doses, and Dibenamine in large convulsant doses, 20 mg/kg, intravenous. Regitine was also tested in norepinephrine induced arrhythmias. Norepinephrine arrhythmias are more difficult to control with intravenous regitine than are epinephrine arrhythmias, and in this sense are more similar to the infarction arrhythmias.