Antibacterial activity of a new thiatetracycline antibiotic, thiacycline, in comparison with tetracycline, doxycycline and minocycline

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Abstract
Thiacycline, a member of a new class (thiatetracyclines) of tetracycline compounds, was more active than minocycline, doxycycline or tetracycline against R+ strains of Escherichia coli, and was also inhibitory to strains of Serratia marcescens and Staphylococcus aureus. Low concentrations of thiacycline or minocycline, but not of tetracycline or doxycycline, reduced or prevented growth of E. coli RP1+ or R100–1 cultures previously induced to tetracycline resistance. It is postulated that sufficient thiacycline (or minocycline) is taken up by R+ cells to ‘by-pass’ tetracycline resistance proteins and thereby inhibit protein synthesis.