Lupus Anticoagulant, Thrombosis, and Fetal Loss

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Abstract
The so-called lupus anticoagulant is an antibody (IgG or IgM or both) that prolongs phospholipid-dependent coagulation tests by binding to epitopes on the phospholipid portion of prothrombinase (a complex of factor Xa, factor Va, phospholipid, and calcium).1 The anticoagulant derives its name from the fact that it was originally described in patients with systemic lupus erythematosus and its site of action was unknown. Although this name has persisted, it is clearly a misnomer, since it has become clear that the lupus anticoagulant is more frequently encountered in patients without lupus, and it is not associated with abnormal bleeding in most . . .