Topical Review: Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike Episodes (MELAS): Current Concepts
- 1 January 1994
- journal article
- review article
- Published by SAGE Publications in Journal of Child Neurology
- Vol. 9 (1) , 4-13
- https://doi.org/10.1177/088307389400900102
Abstract
Mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS) syndrome is one of many mitochondrially inherited multisystem diseases. The features of 110 reported mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes patients are reviewed to define the clinical spectrum of this disease. The clinical disorder, in addition to emerging concepts of genetic etiology, is promoting our understanding of mitochondrial functions. New knowledge may lead to more rational therapies. Finally, the recent revolution in the study of mitochondrial diseases may further our understanding of other degenerative disorders and even aging. (J Child Neurol 1994;9:04-13).Keywords
This publication has 96 references indexed in Scilit:
- A mutation in the tRNALeu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathiesNature, 1990
- Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNALys mutationCell, 1990
- Deletions of mitochondrial DNA in Kearns‐Sayre syndromeNeurology, 1988
- Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathiesNature, 1988
- THE CLINICAL FEATURES OF MITOCHONDRIAL MYOPATHYBrain, 1986
- Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: A distinctive clinical syndromeAnnals of Neurology, 1984
- Myoclonus epilepsy associated with ragged-red fibres (mitochondrial abnormalities): Disease entity or a syndrome?Journal of the Neurological Sciences, 1980
- Lumping or splitting? “ophthalmoplegia‐plus” or kearns‐sayre syndrome?Annals of Neurology, 1977
- Rapid examination of muscle tissueNeurology, 1963
- Retinitis Pigmentosa, External Ophthalmoplegia, and Complete Heart BlockA.M.A. Archives of Ophthalmology, 1958