Alkaline phosphatase activity in cultured skin fibroblasts from fibrodysplasia ossificans progressiva.

Publisher Website
Google Scholar
Abstract
Alkaline phosphatase activity in 4 strains of cultured skin fibroblasts obtained from a patient with fibrodysplasia ossificans progressiva was at the low normal range. The enzyme activity in normal fibroblasts significantly increased at late confluency. The high levels of alkaline phosphatase activity reported in biopsies of lesions may not be genetically determined but are secondary events of local tissue reaction.