Chromosomal distribution of 320 genes from a brain cDNA library
- 1 August 1993
- journal article
- Published by Springer Nature in Nature Genetics
- Vol. 4 (4) , 381-386
- https://doi.org/10.1038/ng0893-381
Abstract
We have determined the chromosomal assignment of 320 brain expressed genes by studying the segregation of polymerase chain reaction (PCR) products in human rodent somatic cell hybrids and by genetically mapping polymorphic cDNAs using the CEPH (Centre d'Etude du Polymophisme Humaine) reference pedigrees and database. These mapped genes can function as markers on the physical map of the human genome, as well as serve as candidate disease gene loci. Distribution of these genes to the human chromosomes correlates well with the GC content of the chromosomes. However, the distribution of these genes does not correlate well with the cytogenetic length of each chromosome.Keywords
This publication has 19 references indexed in Scilit:
- Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1Nature Genetics, 1993
- A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomesCell, 1993
- Single pass sequencing and physical and genetic mapping of human brain cDNAsNature Genetics, 1992
- A Comprehensive Genetic Linkage Map of the Human GenomeScience, 1992
- Chromosomal assignment of 46 brain cDNAsGenomics, 1992
- Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophyNature, 1992
- Sequence identification of 2,375 human brain genesNature, 1992
- Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophyNature, 1991
- Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndromePublished by Elsevier ,1991
- THE ISOCHORE ORGANIZATION OF THE HUMAN GENOMEAnnual Review of Genetics, 1989