Enantioselective Siloxybutylation of Aldehydes and Ketones by Lewis Acid Mediated Ring Opening of Tetrahydrofuran with Lithiated Hydrazones
- 1 January 1993
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1993 (11) , 1092-1094
- https://doi.org/10.1055/s-1993-26007
Abstract
α-Siloxybutylated aldehydes and ketones 4 are synthesized in good overall yields and high enantiomeric purities (ee ≥ 95% ; 81%) by trialkylsilyl trifluoromethanesulfonate mediated ring opening of tetrahydrofuran with lithiated SAMP-/RAMP- or SADP-hydrazones.Keywords
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