Effect of Tributyrin on Circulation and Respiration.

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Abstract
Summary.: The effects of tributyrin on circulation and respiration have been studied by injection of a tributyrin emulsion.On intravenous injection, the effect of tributyrin on circulation is characterized by rapidly appearing bradycardia and a fall in blood pressure, followed by a rise in blood pressure.Bradycardia and the fall in blood pressure are inhibited by vagotomy and procaine. They do not appear with injection into the left ventricle, aorta or large arteries. The effect is probably‐elicited through receptors with afferent pathways in the vagus, and located to the right side of the heart or the lungs. The rise in blood pressure is largely due to contraction of peripheral blood vessels. This rise is not inhibited by tetraethylammonium, hexamethonium, dihydroergotamine, ergotamine or procaine.In the heart‐lung preparation, tributyrin decreases the heart action. The blood flow in the abdominal aorta is reduced, together with a rise in blood pressure after injection of tributyrin.The effect on respiration is characterized by apnoea with a rapid onset, followed by hyperpnoea. Apnoea is not elicited after vagotomy, but appears after administration of atropine or procaine. Injection into the left ventricle, aorta or large arteries does not produce apnoea. Apnoea is probably evoked via receptors in the right side of the heart or the lungs. The hyperpnoea is considered to be produced by central stimulation.Bradycardia, the fall in blood pressure and apnoea associated with injection of tributyrin seem to be elicited in the same way as the Bezold‐Jarisch reflex described earlier.Tributyrin is found to have neither an inhibitory nor a stimulating effect on the superior cervical ganglion.The LD50 of tributyrin on intravenous injection into mice is 320 ± 11 mg/kg.

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