The Nature of the Soluble Antigen from Typhus Rickettsiae

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Abstract
An electron micro-graphic study indicates that the so-called soluble antigen of typhus, and presumably of other rickettsiae, consists of sub-microscopic particles of a capsular substance. This substance adheres to and partly envelops the organisms seen in a centrifugally purified rickettsial suspension. It is broken up by treatment with warm ether; in cold-extracted suspensions, the capsular break-up has begun but has not progressed to the stage of freeing many droplets of the soluble antigen. These droplets are agglutinated by antityphus serum.

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