AN EXPERIMENTAL RAT MODEL OF LOCAL BONE CANCER INVASION AND ITS RESPONSIVENESS TO ETHANE-1-HYDROXY-1, 1-BIS(PHOSPHONATE)

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  • 1 January 1985
    • journal article
    • research article
    • Vol. 45  (5) , 2206-2209
Abstract
Line A Walker carcinoma differs from line B in that it does not elicit hypercalcemia and hypercalciuria when implanted in rats at various sites (s.c., i.m., intraaortically). Walker 256/A, unlike line B, may invade the tibia when implanted i.m. in the adjacent gastrocnemius muscle. This invasion was evaluated by measuring the increased weight of the bone and decreased Ca concentration per unit weight of the tibia by reduced opacity to X-ray and by the presence of tumor cells in the compact bone cortex. Ethane-1-hydroxy-1,1-bis(phosphonate), a diphosphonate derivative, at a dose of 10-30 mg/kg per day s.c., prevented cancer cell invasion of the tibia as judged by the above criteria. This inhibition was obtained with no apparent effect on the growth of Walker 256/A carcinoma.