Contribution to the Study of Subacute Sclerosing Leucoencephalitis with Particular Regard to the Problem of Lipid Chemistry in the Brain

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Abstract
A report is given on two cases of subacute sclerosing leucoencephalitis with particular regard to the problem of lipid chemistry in the brain. In both cases, there was observed a small reduction of total lipids and a stronger fall of phospholipids and cerebrosides, as well as the appearance of cholesterol esters; also a small increase of lipid hexosamine. In the cerebral cortex are found considerably smaller lipid changes: the decrease of phospholipids and the appearance of cholesterol esters. The abnormalities found in the white matter in cases of leucoencephalitis are similar to those described in the demyelinated foci in the cases of multiple sclerosis and in its diffuse form, Schilder''s disease. A small increase of the lipid hexosamine content probably depends on the increase of ganglioside content. It can be assumed that the main course of myelin lipid catabolism in leucoencephalitis does not essentially differ from that seen in multiple sclerosis inclusive of its diffuse form (Schilder''s disease).