Metabolism and acute hepatotoxicity of styrene oxide in rats

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Abstract
The metabolism and acute hepatotoxicity of styrene oxide were studied after i.p. administration of a high dose of 375 mg/kg to adult male rats. Liver glutathione was significantly depleted at 2 h, but became normal at 6 h. The activity of serum glutamicoxaloacetic transaminase increased during the 24 h of study; the activities of alkaline phosphatase and serum glutamic-pyruvic transaminase were elevated at 2 and 24 h, respectively. Decreased body weights and increased liver weights were observed at 24 h. Prothrombin time and urinary urobilinogen concentration were temporarily increased. Urinary mandelic and phenylglyoxylic acids increased during 24 h. Urinary (but not fecal) nonprotein SH contents increased at 2 and 6 h. Results of biochemical tests of liver function suggested a mild liver injury pattern in rats treated acutely with styrene oxide.