Porphyrinuric action of 2-(p-aminobenzenesulphonamido)pyridine (M and B 693). Comparison with sulphanilamide

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Abstract
M and B 693 administered to rats in doses of 0.2-0.9 g./kg. per diem causes an increase in urinary por-phyrin excretion, in this respect resembling sulphanilamide and other amines previously studied. Whereas the degree of porphyrinuria developing after sulphanilamide is roughly proportional to the dose, the higher doses of M and B 693 are relatively less effective. The Na derivatives of M and B 693 and of sulphanilamide administered by mouth in doses of 0.2-0.9 g./kg. per day produce about the same degree of porphyrinuria. While M and B 693 certainly possesses properties which render it potentially toxic, the study of its porphyrinuric action does not indicate that it is essentially any more toxic than is sulphanilamide in this same respect, even allowing for the less ready absorption of the pyridine derivative.