Peritoneal Anaphylaxis in the Rat after Sensitisation with Mouse Antiserum
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 56 (6) , 493-499
- https://doi.org/10.1159/000232064
Abstract
Passive peritoneal anaphylaxis in rats, sensitised with mouse antiserum, had characteristics of an IgE-mediated reaction, in that the serum was heat-labile and pretreatment of the rats with disodium cromoglycate (DSCG), or sodium nivimedone, inhibited the release of both histamine and slow-reacting substance of anaphylaxis (SRS-A). Sodium nivimedone was more potent than DSCG as an inhibitor of histamine release. Peak concentrations of histamine and SRS-A in the peritoneal fluids of the rats, were reached within 2 min of antigen challenge and fell to control levels after 20–30 min.Keywords
This publication has 1 reference indexed in Scilit:
- Release of Chemical Mediators from Partially Purified Human Lung Mast CellsThe Journal of Immunology, 1976