Human urinary excretion of doxifluridine and metabolites during a 5-day chemotherapeutic schedule using fluorine-19 nuclear magnetic resonance spectrometry

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Abstract
The urinary excretion of doxifluridine (5′ dFUrd) and its metabolites was determined during five days of chemotherapy using fluorine-19 nuclear magnetic resonance spectrometry. The daily urinary excretion of 5′ dFUrd and its metabolites was high (∼-100% of the 5′ dFUrd administered) and nearly constant through out the treatment. By far the major excreted compounds were unchanged 5′ dFUrd and α-fluoro-β-alanine which made up respectively ∼-40% and ∼-50% of the total. Neither accumulation of 5′ dFUrd nor significant modifications in its metabolism were observed during the treatment.