(Acylaryloxy)acetic acid diuretics. 4. Indeno[5,4-b]furan-2-carboxylic acids

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Abstract
Investigation of the chemistry of the potent new uricosuric diuretic indacrinone (MK-196) led to a class of novel annulated derivatives, indeno[5,4-b]furan-2-carboxylic acids. The structural requirements for optimal diuretic and uricosuric activity of the tricyclic analogs differed from those of their (indanyloxy)acetic acids counterparts. Most notably, the tricyclic analogs were 2-4 times more natriuretic than the corresponding (indanyloxy)acetic acids when administered orally to rats and in chimpanzees uricosuria was observed only in those indenofurans having a nuclear aryl substituent.

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