Colloid milium: a final degeneration product of actinic elastoid

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Abstract
Serum amyloid P component (SAP) is present not only in all types of cutaneous amyloidosis, but also in the normal dermal clastic fibers as well as abnormal elastic‐fibers, such as clastotic degeneration of clastic fibers in actinic keratosis. It was previously postulated that the colloid substance in colloid milium is a final degeneration stage of actinic clastosis. In a lesion of colloid milium SAP was intensely positive with an indirect iinmuiiofluorescence method using rabbit antiserum to human SAP. Electron microscopy of the colloid lesion revealed components of normal elastic fibers as well as those of actinic elastoid as seen in actinic clastosis. It is concluded that the colloid substance derives, at least in major part, from elastic fibers through actinic degeneration.