IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE REGION (VH) MARKER ASSOCIATED WITH CROSS-REACTIVE IDIOTYPES IN MAN
- 1 January 1977
- journal article
- research article
- Vol. 30 (2) , 233-241
Abstract
The VH specificities of 2 rabbit antisera raised against the H chains of 2 human Ig[immunoglobulin]M cold agglutinins were studied with the aid of proteins on which the VH sequence data are available. They recognized a new VH antigen (VHMar), which may represent a subgroup of VHI. This antigen is found on anti-Ii[blood group antigens] antibodies which have cross-reactive idiotypes. It is moderately well-expressed in normal .gamma.-globulin and strongly expressed on 8% of unselected myeloma and macroglobulinemia proteins. There is evidence to sugest that a proportion of the cross-reactive idiotypes among the anti-Ii antibodies involve this VH antigen.This publication has 27 references indexed in Scilit:
- Cross idiotypic specificity among heavy chains of macroglobulins with blood group I and i specificitiesNature, 1975
- Partial amino acid sequence of an IgA2 human immunoglobulin heavy chainBiochimica et Biophysica Acta (BBA) - Protein Structure, 1975
- PRIMARY STRUCTURE OF A MONOCLONAL IGA-IMMUNOGLOBULIN (IGA TRO) .2. AMINO-ACID SEQUENCE OF H-CHAIN, ALPHA-TYPE, SUBGROUP-3 - STRUCTURE OF COMPLETE IGA-MOLECULE1975
- Cross idiotypic specificity among cold agglutinins in relation to combining activity for blood group-related antigens.1974
- Switch point in .mu. heavy chains of human IgM immunoglobulinsBiochemistry, 1974
- SIMILARITIES IN THE LIGHT CHAINS OF ANTI-γ-GLOBULINS SHOWING CROSS-IDIOTYPIC SPECIFICITIESThe Journal of Experimental Medicine, 1974
- [The primary structure of a monoclonal IgM-immunoglobulin (macroglobulin Gal.), I. The amino acid sequence of the L-chain of kappa-type, subgroup I (author's transl)].1973
- Similar Idiotypic Specificities in Immunoglobulin Fractions with Different Antibody Functions or Even without Detectable Antibody FunctionProceedings of the National Academy of Sciences, 1971
- Bence Jones proteins and light chains of immunoglobulins. IV. Immunochemical differentiation among proteins within each of the three established kappa-chain classes.1971
- THE COVALENT STRUCTURE OF AN ENTIRE γG IMMUNOGLOBULIN MOLECULEProceedings of the National Academy of Sciences, 1969