? Sequences mediate DNA rearrangements in Saccharomyces cerevisiae
- 1 October 1982
- journal article
- Published by Springer Nature in Current Genetics
- Vol. 6 (1) , 55-61
- https://doi.org/10.1007/bf00397642
Abstract
A solo δ sequence flanking the 5′ end of the ADHII structural gene, ADR2, can promote a number of DNA rearrangements some of which were investigated in detail. In a selective system haploid mutants were screened in which a solo S sequence flanking ADR2 had been joined to a Ty element. Three different types of events can create such a structure: Reintegration of a Ty sequence at the δ-ADR2 site, inversion of ADR2 and flanking material, and transposition of ADR2 along with 3′ flanking material. The involvement of reciprocal or non-reciprocal exchange mechanisms in creating such events are discussed.Keywords
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