S-PHASE RATE AS A PREDICTOR OF EARLY RECURRENCES IN CARCINOMA OF THE UTERINE CERVIX

  • 1 July 1987
    • journal article
    • research article
    • Vol. 7  (4) , 807-810
Abstract
Flow cytometric measurements of ploidy level and S-phase rate were performed in a prospective study of 165 patients with cervical squamous cell carcinoma. Patients were followed-up for 24 months after initial treatment. There was no significant difference in recurrence rate between patients with peri-diploid tumors (1.8c-2.2c) and aneuploid tumors. The S-phase rate (evaluable in 133 cases), which previously has been studied only occasionally in cervical carcinomas, was correlated with early relapses. Significantly more relapses were found in tumors with S-phase rates .gtoreq. 20% than among tumors with S-phase rates < 20% (.chi.2 = 9.54, p < 0.01). A higher relapse rate among tumors with S-phase rates .gtoreq. 20% was found even after taking staging into consideration (Cochran - Mantel - Haenszel test, p < 0.01). Thus, besides staging, evaluation of the S-phase rate yielded additional prognostic information.