A convenient preparation of N-acylpyroglutamic acid.
- 1 January 1981
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 29 (9) , 2699-2701
- https://doi.org/10.1248/cpb.29.2699
Abstract
Pyroglutamic acid reacted with acyl chloride in the presence of triethylamine in acetonitrile, yielding N-acylpyroglutamic acid without epimerization by way of mixed anhydride formation followed by intramolecular N-acylation.Keywords
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