Natural SIV Hosts: Showing AIDS the Door
Top Cited Papers
- 9 March 2012
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 335 (6073) , 1188-1193
- https://doi.org/10.1126/science.1217550
Abstract
Lessons from SIV: HIV infection in humans is a chronic infection and, if left untreated, the majority of infected individuals will succumb to AIDS. Many species of African nonhuman primates are chronically infected with simian immunodeficiency virus (SIV); however, in the majority of these species, the animals remain healthy despite the presence of high viral loads. Chahroudi et al. (p. 1188 ) review the underlying immune mechanisms that help protect natural hosts from progressing to AIDS and how these responses differ from what is observed in HIV-infected humans and SIV-infected nonhuman primate species that develop AIDS.Keywords
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