Cytokine polymorphisms and chronic lung disease in small preterm infants

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Abstract
There was no significant association between the genotype or the allelic frequency of the TNFα or IL1β exon5 or IL1 receptor antagonist (IL1RA) polymorphism with CLD and the duration of intermittent mandatory ventilation supplement. The most common genotypes for TNFα-308 polymorphism for CLD and their healthy control infants were the G homozygote. The proportions of A homozygote/G heterozygote for the TNFα-308 polymorphism for CLD and their healthy controls were 5.4/21.4/73.2% and 5.4/32.1/62.5% respectively. The most common genotypes for IL1RA for CLD and their healthy controls were the I/I homozygote. The proportions of I homozygote/II heterozygote for IL1RA for CLD and their healthy controls were 87.5/12.5% and 85.7/14.3% respectively. The most common genotypes for IL1β exon 5 for CLD and their healthy controls were the E1 homozygote. The proportions of E1 homozygote/E2 heterozygote for IL1β exon 5 for CLD and their healthy controls were 92.9/7.1% and 94.6/5.4% respectively. We conclude that TNFα-308, IL1RA, and IL1β exon 5 polymorphisms are not useful markers for predicting the susceptibility of the Chinese population in Taiwan to CLD.

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