Copper Deficiency in Infants
- 1 September 1956
- journal article
- research article
- Published by American Medical Association (AMA) in A.M.A. Journal of Diseases of Children
- Vol. 92 (3) , 254-265
- https://doi.org/10.1001/archpedi.1956.02060030248002
Abstract
Introduction Low serum copper concentrations are characteristic of the newborn infant * and are known to occur in nephrosis,† in sprue,7and in the hepatolenticular degenerative disorder of Wilson.‡ In addition, Zurukzoglu-Sklavounou in Switzerland,11Stransky in the Phillipine Islands12and Axtrup in Sweden,13although attaching little or no significance to the findings, have published data indicating the sporadic occurrence of hypocupremia in infants with hypochromic, microcytic anemia. On the other hand, it is generally concluded that the serum copper concentration is normal or elevated in iron deficiency anemia and data supporting this position have been reported by Axtrup,13Brenner,14Freudenberg,15and by Lahey and co-workers,9as well as by the previously cited authors.§ Infants maintained on nearly exclusive milk diets are likely to develop a microcytic, hypochromic anemia typical of iron deficiency and closely resembling the anemia produced in swine by copper-deficient diets.‖Keywords
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