The Sydney System: Auto‐immune gastritis

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Abstract
The association of gastric auto‐immunity with chronic gastritis has been recognized for more than 30 years. Despite this, little is known about the initiation of auto‐immune gastric mucosal injury or the role of gastric auto‐antibodies in this disease process. The current review describes recent progress in our understanding of these fundamental questions on the origin and progression of auto‐immune gastritis.In addition, evidence is presented (epidemiologic, clinical, pathologic and experimental) that strongly supports the view that auto‐immune gastritis is a distinctive category of chronic gastritis with significant long‐term sequelae.