Power failure: why small sample size undermines the reliability of neuroscience
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- 10 April 2013
- journal article
- review article
- Published by Springer Nature in Nature Reviews Neuroscience
- Vol. 14 (5) , 365-376
- https://doi.org/10.1038/nrn3475
Abstract
A study with low statistical power has a reduced chance of detecting a true effect, but it is less well appreciated that low power also reduces the likelihood that a statistically significant result reflects a true effect. Here, we show that the average statistical power of studies in the neurosciences is very low. The consequences of this include overestimates of effect size and low reproducibility of results. There are also ethical dimensions to this problem, as unreliable research is inefficient and wasteful. Improving reproducibility in neuroscience is a key priority and requires attention to well-established but often ignored methodological principles.Keywords
This publication has 92 references indexed in Scilit:
- Raise standards for preclinical cancer researchNature, 2012
- The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-AnalysisNeuropsychopharmacology, 2011
- Lower incidence of cerebral infarction correlates with improved functional outcome after aneurysmal subarachnoid hemorrhageJournal of Cerebral Blood Flow & Metabolism, 2011
- Association of 5-HTT gene polymorphisms with migraine: A systematic review and meta-analysisJournal of the Neurological Sciences, 2011
- Delayed reward discounting and addictive behavior: a meta-analysisPsychopharmacology, 2011
- Effect of pharmaceutical treatment on vasospasm, delayed cerebral ischemia, and clinical outcome in patients with aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysisJournal of Cerebral Blood Flow & Metabolism, 2011
- Systematic Survey of the Design, Statistical Analysis, and Reporting of Studies Published in the 2008 Volume of the Journal of Cerebral Blood Flow and MetabolismJournal of Cerebral Blood Flow & Metabolism, 2010
- Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment ResponseNeuropsychopharmacology, 2010
- Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studiesEuropean Journal of Human Genetics, 2010
- Overcoming the Winner’s Curse: Estimating Penetrance Parameters from Case-Control DataAmerican Journal of Human Genetics, 2007