Long-term selective IgG immunoadsorption improves Rasmussen's encephalitis
- 1 July 1998
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 51 (1) , 302-305
- https://doi.org/10.1212/wnl.51.1.302
Abstract
We report that long-term selective immunoglobulin G immunoadsorption by protein A (PAI) improved seizure frequency and neuropsychological deficits in a 16-year-old patient with severe treatment-resistant Rasmussen9s encephalitis (RE). Clinical improvement correlated with reduction of antiglutamate receptor 3 antibodies. The efficacy of PAI in our patient supports the autoimmune hypothesis of RE and suggests its application to avoid, or at least delay, functional hemispherectomy in selected cases.Keywords
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