The Action of Valepotriates on the Synthesis of DNA and Proteins of Cultured Hepatoma Cells

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Abstract
Valtrate, didrovaltrate and deoxido-didrovaltrate were compared for toxicity on cultured rat hepatoma cells (HTC strain) and for their effects on the synthesis of DNA and proteins. Despite lacking the epoxide function in C8-C11 position in its molecular structure, deoxido-didrovaltrate has a similar cytotoxicity to didrovaltrate. The toxicity of both these drugs is two times lower than that of valtrate. Incorporation tests with 3H-thymidine and 3H-leucine on cultured HTC cells revealed that a low dose of valtrate, rapidly and extensively inhibits the synthesis of both DNA and proteins. Didrovaltrate and deoxido-didrovaltrate have the same effect, but at double the dose.