Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults: meta-analysis of randomised trials
Top Cited Papers
- 14 May 2008
- Vol. 336 (7653) , 1121-1123
- https://doi.org/10.1136/bmj.39548.738368.be
Abstract
Objective To quantify the relative risk reductions achieved with different regimens to lower blood pressure in younger and older adults.Design Meta-analyses and meta-regression analyses used to compare the effects on the primary outcome between two age groups (0.09). The meta-regressions also showed no difference in effects between the two age groups for the outcome of major cardiovascular events (<65 v ≥65; P=0.38).Conclusions Reduction of blood pressure produces benefits in younger (<65 years) and older (≥65 years) adults, with no strong evidence that protection against major vascular events afforded by different drug classes varies substantially with age.Keywords
This publication has 14 references indexed in Scilit:
- Treatment of Hypertension in Patients 80 Years of Age or OlderNew England Journal of Medicine, 2008
- 2007 Guidelines for the Management of Arterial HypertensionJournal Of Hypertension, 2007
- The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2 – therapyCanadian Journal of Cardiology, 2007
- Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004—BHS IVJournal of Human Hypertension, 2004
- Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trialsThe Lancet, 2003
- 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertensionJournal Of Hypertension, 2003
- The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood PressureThe JNC 7 ReportJAMA, 2003
- Better blood pressure control: how to combine drugsJournal of Human Hypertension, 2003
- Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studiesThe Lancet, 2002
- Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Research Group.2000